© Global Journal Of Pure And Applied Sciences . 2002. Vol. 8 No. 1
Publisher: Bachudo Science Co. Ltd
Effect of Ricinus Communis Seed Oil (CASTOR OIL) On Experimental (ETHANOL-INDUCED) Gastric Ulcer In Rats.
F. P. Ching, D. N. Bala, R. B. Okoh
KEYWORDS: Ethanol, Gastric ulcer, Castor oil, Cimetidine and Omeprazole.
ABSTRACT:Ricinus communis seed oil (castor oil) is used to relieve some gastrointestinal symptoms and as a bowel evacuate as a preliminary to intestinal examination. The study was aimed at the investigation of the effects of castor oil on ethanol induced gastric ulcer model in rats. Pretreatment of rats orally with castor oil (1 ml/rat) significantly (p<0.05) protected the rats (60%) from ulcers produced by 99% ethanol, with 1.7 ± 0.6 mm ulcer index compared to the control (4.9 ± 0.3rnm). Similar. pretreatment with Cimetidine (200mg Kg ^-1) protected the rats only by 40% with 2.8 ± 0.5rnm ulcer index. Gastric ulcers in rats initially challenged with 99% ethanol were inhibited by 60%, 40% and 20%. wIth corresponding ulcer index of 2.6 + 0.5mm and 3.1 + 0.2mm and 3.6 + 0.8mm by Castor oil, rnl, Cimetidine and Omeprazole (20mgkg-1 p.o) respectively, compared to the control (4. 6 ± 0.4mm). The result show that castor oil has both preventive effects and curative effect in ethanol induced gastric ulcer.
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