Publisher: Bachudo Science Co. Ltd

Effects of Cyanide and Various Concentrations of Scopoldin: On Some Serum Lipid Levels of Wistar Rats

Lawrence U. S. Ezeanyika, Onyechi Obidoa, Jonathan W. Ulea, Ismaila A. Umar.
KEYWORDS: Scopoletin, Cyanide, Serum Lipids

ABSTRACT:

The effect of cyanide and various concentrations of scopoletin on serum ch,olesterol, phosphoHpids and triacylglycerols of wistar rats were studied for a period of 2 weeks. To achieve this, 60 wistar rats were divided into 6 groups of 10 each and administered intragastric doses of scopoletin (7µg/ml, 21 µg/ml and 35µg/ml per kg body weight respectively, groups I - Ill) daily. The rats were sacrificed at intervals of 7 days. The animals in group IV received 1.8mg/ml cyanide per kg body weight daily. The animals in group V were administered equivalent amount of 10% dimethyl sulphoxlde (DMSO) which served as the vehicle for the administration of scopoletin while those in group VI received distilled water. The amounts of scopoletin and cyanide administered to the rats in group I and IV correspond to the amount taken by a 70kg man in cassava consuming populations. The results of the study show that scopoletin elicited a significant {p < 0.05) ... and dose-dependent increase in serum cholesterol and phospholipids after two (2) weeks. There was also a significant increase (p < 0.05} in the serum triacylglycerol level of the scopoletin treated animals, which was however dose independent. The results obtained. from the cyanide treated group compared with the scopoletin treated groups except that it significantly reduced (p < 0.05) serum cholesterol after two weeks. The findings of this work suggest that scopoletin could lead to altered lipid metabolism and may thus predispose to lipid related diseases.


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