© Global Journal Of Pure And Applied Sciences . 2010. Vol. 16 No. 1
Publisher: Bachudo Science Co. Ltd
Influence of Vitamin B-12 Complex Injection (ELDERVIT-12) On Gentamicin Nephrotoxicity In Rats: A Preliminary Study
Shaibu O. Bello, A. Chika
KEYWORDS: Gentamicin, toxicity, B-complex, ascorbic acid, rats
ABSTRACT:Objectives: To assess the effect of vitamin B-12 complex injection on the nephrotoxicity of gentamicin. Design: Experimental study using a pre-validated model. Subject: Adult Swiss albino rats weighing 140-214g, Generic gentamicin sulphate injection and Vitamin B-12complex injection containing 2500mcg Cyanocobalamin, 12mg Niacinamide, 0.7 mg Folic acid and 150 mg Ascorbic acid in twin ampoules to be combined fresh before administration. Setting: A pharmacological research laboratory in a tertiary instituteResults: In Swiss albino rats, both 0.5mls/kg/day and 1mls/kg/day of B-12 complex injection for 5 days significantly and dose dependently exacerbated the increase in serum urea and creatinine caused by 80mg/k/day of gentamicin while both doses of B-12 complex injection given for 10 days significantly and dose dependently ameliorated the increase in serum urea and creatinine caused by 80mg/k/day of gentamicin (reversal of effect). Conclusion: 0.5mls/kg/day of B-12 complex injection for 5 days exacerbated gentamicin nephrotoxicity while the same dose for longer duration or 1ml/kg/day of B-12 complex ameliorated the toxicity. The exacerbation is probably due to the ascorbic acid component while the reversal is probably due to the other components acting directly or through a time dependent pharmacological advantage.
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