Publisher: Bachudo Science Co. Ltd

Effect of Aqueous Extract of Garcinia Kola On Some Liver Enzymes of Rats With Carbon Tetrachloride Induced Liver Damage

C. Onabu, E. O. Anosike, G. O. Ibeh
KEYWORDS: Garcinia kola, Carbon tetrachloride (CCl4), Aspartate amino transferase, Alanine aminotransferase and Alkaline phosphatase.

ABSTRACT:

The effect of Garcinia kola aqueous extract on the activities (lU/L) of some liver enzymes was determined in serum of rats injected intraperitoneally with carbon tetrachloride at different doses of 0.33, 0.66, 0.99 and 1.32mL The enzymes studied were Aspartate amino transferase (AST), Alanine aminotransferase {ALT) and alkaline phosphatase (ALP). The 21 day cummulative toxicity study showed a significant increase in the activities of AST, ALT and ALP (Ps0.001) in serum of rats injected with different doses of CCl4. The mean values (IU/L) in serum were: for AST 59.00 ± 0.30 without CCl4 (control) and 107.67±0.87, 154. 10± 0.08, 186. 12 ± 0.83 and 55.02±0.62 with CCl4, 0.33, 0.66, 099 and 1.32ml respectively; for ALT 54.0 ±0,15 without CCl4 (control) and 98.37±0.21, 109.87±0.19,129.40±0.37, and 185.51±3.24 with CCl4 0.33. 0.66, 0.99 and 1.34ml respectively; for ALP, 54.90± 0.20 without CCl4 (control) and 65.20±0.09, 85.34± 053, 95 90 ± 2 05 and 1 T1 .15 ± 1.24 with CCl4, 0.33, 0.66, 0 99 and 1,32ml respectively). The increase in the activities was significantly higher (ps0.001) at higher doses of CC'4. The aqueous extract from the seeds of Garcinia kola (w/v) at doses of 20g/50ml, 40g/50ml given orally for 7 days, 14 days and 21 days respectively reduced the activities of three microsomal enzymes in serum of rats injected with different concentrations of CCl4. The reduction in the enzyme activities was


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