© Global Journal Of Pure And Applied Sciences . 2005. Vol. 11 No. 3
Publisher: Bachudo Science Co. Ltd
Comparative Efficacy of Crude Aqueous Extract of Mangiferia Indica, Carica Papaya and Sulphadoxine Pyrimethamine On Mice Infested With Malaria Parasite In Vivo
F. O. Uhegbu, Ify Elekwa, Chinyere Ukoha
KEYWORDS: Malaria parasites, malaria, antimalaria potency, red blood cells, sulphadoxine pyrimelhamine, Mangifera indica. Carica papaya
ABSTRACT:The comparative efficacy of a chemotherapeutic antimalarial drug complex- sulphadoxine-pyrimethamine (maloxine) and two different leaf extracts: Mangifera indica (mango) and "Carica papaya (paw-paw) were investigated on malaria-infested mice using Plasmodium beighei the rodent malaria species. Maloxine had the highest anti-malaria efficacy; reducing the parasite count from average count of 9.4 L0.04 to 1.4 J 0.05 after six days of treatment. The paw-paw leaf extract reduced the malaria parasite count from an average of 9.2 ±0.06 to 2.6 ± 0.06; while lh:J mango leaf extract showed a reduction from 9.8 ±0.01 to 3.2 :l: 0.03 after six days of treatment. However, a combination of the two leaf extracts (1: 1) exhibited a higher anti-malaria efficacy than the separate leaf extracts, reducing he parasite countfrom 9.4 ± 0.031 to 2.0 ± 0.15. The public health implications of these findings are discussed.
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