Publisher: Bachudo Science Co. Ltd

Effect of Alcohol-Kolanut Interaction On Brain Monoamine Oxidase Activity In Wistar Albino Rats

G. O. Obochi, A. B. Utubaku, A. E. Abara, M. U. Eteng, E. U. Eyong, M. E. Obi-abang, P. S. Malu, I. B. Umoh
KEYWORDS: alcohol. kolanut. caffeine and monoamme oxidase

ABSTRACT:

Effect of alcohol-kolanut interaction on brain monoamine oxidase activity in wistar albino rats was studied. Sixty Wistar albino rats were divided into six groups of ten (10) rats per group. Group 1 was the control, while groups 2 through 6 were treated with alcohol (10%v/v), kolanut extracts, caffeine, alcohol and kolanut, and alcohol and caffeine respectively. The experiment lasted for twenty one (21) days. Brain levels of monoamine oxidase. noradrenaline and adrenaline were assayed. The results showed that alcohol-kolanut interaction increased the monoamine oxidase activity but however, decreased noradrenaline and adrenaline levelsThis might suggest that alcohol-kolanut interaction did not damage the genes encoding monoamine oxidase but it induced its expression. slowed down the release of neurotransmitters in the brain, thus. reducing the risk of schizophrenia. stroke and hypertension


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