© Journal Of Chemical Society Of Nigeria (jcsn) . 2010. Vol. 35 No. 1
Publisher: Chemical Society of Nigeria
Synthesis of Some Sulphonyl Derivatives of Aminothiazole and Antimicrobial Screening
L. N. Obasi, P. O. Ukoha, K. F. Chah
KEYWORDS: Sulphonamides, 2-aminothiazole, antimicrobial, spectroscopy
ABSTRACT:N-(thiazol-2-yl)-2-naphthalenesulphonamide,[NSAT],N-(thiazol-2-yl)ethanesulphonamide, [ESAT] and N(thiazol-2-yl)-4-chlorobenzenesulphonamide,[CBSAT] were synthesized from the condensation reactions of 2-aminothiazole, [AT] and 2-naphthalene sulphonyl chloride, [NS] ,ethanesulphonylchloride,[ES] and 4-chlorobenzene sulphonylchloride, [CBS] in acetone respectively. Melting point, UV/Visible, NMR and IR Spectroscopies were employed in the characterization of the compounds. Antimicrobial screening of the compounds were carried out in vitro on Staphylococcus aureaus, Candida albicans, Escherichia coli and Pseudomonas aeruginoisa. The Inhibition Zone Diameter (IZD) of the compounds on these microbes was noted. The compounds showed significant activities against Staphylococcus aureaus and Escherichia coli, however, only N-(thiazol-2-yl)ethanesulphonamide showed activity against Candida albicans. Their Minimum Inhibition Concentration (MIC) was also determined. The compounds were not active against Pseudomonas aeruginoisa.
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