Publisher: Chemical Society of Nigeria

Synthesis of Some Sulphonyl Derivatives of Aminothiazole and Antimicrobial Screening

L. N. Obasi, P. O. Ukoha, K. F. Chah
KEYWORDS: Sulphonamides, 2-aminothiazole, antimicrobial, spectroscopy

ABSTRACT:

N-(thiazol-2-yl)-2-naphthalenesulphonamide,[NSAT],N-(thiazol-2-yl)ethanesulphonamide,  [ESAT]  and  N(thiazol-2-yl)-4-chlorobenzenesulphonamide,[CBSAT]  were  synthesized  from  the  condensation  reactions  of 2-aminothiazole,  [AT]  and  2-naphthalene  sulphonyl  chloride,  [NS]       ,ethanesulphonylchloride,[ES]  and 4-chlorobenzene  sulphonylchloride,  [CBS]  in  acetone  respectively.  Melting  point,  UV/Visible,  NMR  and  IR Spectroscopies  were  employed  in  the  characterization  of  the  compounds.  Antimicrobial  screening  of  the compounds  were  carried  out  in  vitro  on  Staphylococcus  aureaus,  Candida  albicans,  Escherichia  coli  and Pseudomonas  aeruginoisa.  The  Inhibition  Zone  Diameter  (IZD)  of  the  compounds  on  these  microbes  was noted.  The  compounds  showed  significant  activities  against  Staphylococcus  aureaus  and  Escherichia  coli, however,  only  N-(thiazol-2-yl)ethanesulphonamide  showed  activity  against  Candida  albicans.  Their Minimum  Inhibition  Concentration  (MIC)  was  also  determined.  The  compounds  were  not  active  against Pseudomonas aeruginoisa.  


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