Publisher: Chemical Society of Nigeria

A Dammarane Triterpenoid Ester From Combretum Glutinosum Perr. Ex. Dc., Stem Bark

N. F. Amako, J. O. Amupitan
KEYWORDS: Combretum glutinosum perr. ex. dc., 3 beta acetoxydammar-21(22)-ene, 2,4-di-tert-butyl phenol, and beta amyrin2

ABSTRACT:

Petroleum ether extract of Combretum glutinosum stem bark was chromatographed on silica gel column using petroleum ether: ethylacetate (19:1) followed by a gradient of ethylacetate up to 100%, and finally washed with methanol. Similar fractions were pooled together on the basis of their RF values and further purified by preparative thin layer chromatography using petroleum ether: ethylacetate (19:1). This afforded a triterpenoid with dammarane carbon skeleton. 1HNMR and 13CNMR analysis enabled its identification as 3 ß- acetoxydammar-21(22)-ene.  Other compounds isolated were 2,4-di-tert-butylphenol and beta amyrin, their  identity were also ascertained using GC/MS comparison with authentic samples. 


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