Publisher: University of Port-harcourt Teaching Hospital

A Decade of Anti-Retroviral Therapy In Nigeria: Efficacy of First Line Regimens In Treatment-Naive HIV/AIDS Patients.

Ejiji S. Isa, Comfort A. Daniyam, Michael Iroezindu
KEYWORDS: HIV, antiretroviral drugs, efficacy, Nigeria

ABSTRACT:

Background: The proportion of persons who become infected with resistant strains of HIV may be increasing. We assessed the efficacy of first line anti-retroviral (ARV) regimens since they were first introduced in Nigeria.Methods: A descriptive prospective cohort study comparing baseline body mass index (BMI), CD+4 counts thand viral load (VL) with those obtained at 6 month of highly active antiretroviral therapy (HAART) in 300 HIV infected treatment-naive patients. Data were analysed with Epi-Info version 3.3 software and a probability value < 0.05 was considered significant.2Results: The mean BMI at baseline of 22.9±4.6 kg/m 2thincreased to 24.6±4.4 kg/m at 6 month of HAART. Therefore, the absolute increase in mean BMI was 21.7kg/m and was statistically significant p<0.05. The median CD4+ counts at baseline and at the end of the study shows counts of 127 cells/µl and 236 cells/µl respectively. This corresponds to a median increase of 109 cells/µl but was not statistically significant p=>0.05.  When immunological response was measured as an increase from baseline of at least 50cells/µl, the proportion of patients with CD4+ count increase = 50cells/µl at the sixth month of HAART was 68%. The baseline median viral load was log 4.90, log (IQR 3.41-6.41) but became 10 10 thless than log 2.60, log (IQR 2.60-5.26) at 6 month of 10 10 HAART. Hence, a median viral load reduction of at least log 2.30 p<0.05 was achieved.  10Conclusion: This study supports the belief that using limited ARV regimens can result in acceptable treatment outcomes many years after they were first introduced.


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