Publisher: Association of Reproductive Biologist of Nigeria

The Effect of Low‑Dose Ketamine (PREEMPTIVE DOSE) On Postcesarean Section Pain Relief

Forozan Milani, Katayoun Haryalchi, Seyedeh Hajar Sharami, Roya Faraji, Maryam Asgharnia, Fatemeh Salamat, Seyedeh Saeedeh Hashemi
KEYWORDS: Ketamine, low dose, pain relief, preemptive

ABSTRACT:

Background: Postsurgical pain is the main cause of anxiety in patients; therefore, analgesics (adjuvants) such as preemptive doses of ketamine with minimal adverse effects would be beneficial. However, studies are needed regarding their efficacy. Aim: To determine the preemptive effect of intravenous ketamine on pain intensity and need to opioids in cesarean section which performed under spinal anesthesia. Subjects and Methods: The study was a randomized, double‑blinded, clinical trial involving 60 term parturients for cesarean, using random block method, they were divided into two groups of each. The case group received ketamine with dose of 0.2 mg/kg and the control one normal saline with the same volume. Pain intensity was compared in 0,30,60,90,120,150, and 180 min and 6,12,18, and 24 h after surgeries with visual analog scale (VAS) index. The average opioid usage was compared during 24 h after those too. Final analyses were done with Mann‑Whitney, Chi‑square, and Spss.v. 16 (P < 0.05 was meaningful level). Results: There was not significant statistical difference on average VAS during interruptedtimes (F = 0.15, P = 0.70). Average dosage of diclofenac suppository and mean time for taking the first dosage of opioids have not statistical difference too (respectively; P = 0.76, P = 0.87). Average dose of pethidine was lesser than placebo statistically. It means, the case group did not take pethidine but this amount was 6 (20%) in the control one (P = 0.02). Conclusion: Taking thepreemptive dosage of ketamine (0.2 mg/kg) before cesarean could act as a probably model for decreasing opioid consumption.


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