Publisher: Nigerian Society For Microbiology

Hepatitis B and C Seropositivity In A Cohort of HIV-Positive Patients In Ilorin, North-Central Nigeria

Udeze A. O., Ali U. M., Adeoye P. A., Odugbesi A. E., Sule W. F., Okonko I. O.
KEYWORDS: dual infection, hepatitis B, hepatitis C, HIV-positive, Nigeria, seropositivity

ABSTRACT:

 Since HIV, HBV and HCV share common routes of transmission and acquisition, HIVinfected patients are likely exposed to HB and C viruses. We hypothesised that there was no difference between prevalence rate of HB and C infections among HIV-infected patients accessing healthcare at HIV and AIDS section of University of Ilorin Teaching Hospital, Ilorin, Nigeria. This is a hospital-based cross sectional study. After obtaining ethical approval, we consecutively selected consenting 356 participants from whom we obtained pertinent sociodemographic data using questionnaire forms; after which we aseptically collected blood samples and prepared plasma from each. The latter were tested, using ELISA, for presence of HBsAg and anti-HCV antibody. The results were analyzed using t-test and binary logistic regression. Of the 356 (128 males and 228 females: age range 7 months-70 years, mean age 36.5 years) HIV-infected participants, 114 (32.0%) and 14 (3.9%) were respectively positive for HBsAg and anti-HCV antibody; these respectively represented dual HIV-HBV and HIV-HCV infection rates. The HIV-positive participants had more than 11 times (p=0.001) likelihood of being HBsAg positive than being anti-HCV antibody positive. Group-specific prevalence rate was also higher for HIV-HBV dual infection. Conclusively, the HIV-infected participants had significantly higher HB rate compared to HC, this was suggestive of higher infectiousness of HBV and greater exposure to HBV than HCV. The only variable predictive of HIV-HCV or HIVHBV dual infection was education. But, occupation and history of blood transfusion were respectively predictive of HIV-HBV and HIV-HCV dual infection among the study participants. 



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